ABSTRACT
Background: Coronavirus disease 2019 (COVID-19) was suspected to trigger angioedema attacks, or cause more severe COVID-19 disease in patients with Hereditary angioedema (HAE). Our objective was to evaluate the severity of COVID-19 and its impact on disease control in patients with severe HAE in long-term prophylaxis(LTP) with subcutaneous C1-inhibitor( SC C1-INH). Method(s): We p erformed a retrospective s tudy of p atients w ith s evere course of HAE who maintained LTP with SC C1-INH during the pandemic. Date were collected under conditions of daily clinical practice. Patients were evaluated at least 2 times after switching to LTP with SC C1-INH. We analyzed COVID19 vaccine application and tolerance, COVID19 infection, disease control after COVID19 infection and the quality-of- life. Result(s): We evaluated 18 patients(12 female) who switched from LTP with IV C1-INH to LTP with SC C1 INH. Switching was followed by a significant decrease in the number of attacks, visits to the emergency department, and use of rescue dose of IV C1-INH or icatibant, as well as improved disease control (Angioedema Control Test). All patients were vaccinated against COVID19 (37 doses of mRNA vaccine and 4 doses of viral vector vaccine). Nor severe neither moderate adverse reactions were observed. 5 patients were infected with COVID19 (one 30 years-old female patient was infected twice) and had mild symptoms. None of the patients needed a hospital admission. Only one of the patients had worsening of the disease control after COVID19 infection and long -term post COVID repercussion (persistent headache and depressive mood). One of the infected patients was pregnant (7 gestational weeks) and had asymptomatic COVID19 infection with no impact on pregnancy. Conclusion(s): In our cohort of patients LTP with SC C1 INH and correct vaccination against COVID19 have shown that can maintain severe HAE patients with good clinical control even when infected with the virus.
ABSTRACT
The 2022 American Society for Clinical Pharmacology and Therapeutics (ASCPT) Annual Meeting held virtually, with "Disruptive innovation" as the motto, offered attendees an outstanding scientific program focused on clinical pharmacology, translational medicine, drug discovery and drug development. It is the most important event for scientists involved in clinical pharmacology and translational medicine. The ASCPT conference offers scientists from different professional scopes and around the world the perfect opportunity to discuss emerging science. It focuses on improving the understanding and use of existing drug therapies and developing safer and more effective treatments for the future. Oral and poster presentations were available for participants during the running of the conference to accommodate the different time zones. Presentations covered the latest research with the option to ask questions after each presentation via a chat function. Discussion boards were available to provide networking opportunities for virtual attendees.
ABSTRACT
Currently, more than 290 million students in the world are not attending classes due to the pandemic caused by COVID-19. In this sense, many educational centers have adapted classroom teaching to a non-classroom setting in response to the crisis. However, the change of modality from face-to-face to virtual education cannot suppose only a decision in which it is intended to replace the first one using some computer tools as video conferences. With this preamble, the need to systematically map digital competencies in Latin American higher education teachers raises since there are no records of the status of teacher's digital competencies in this part of the world before the pandemic. Therefore, this work examines the scientific literature published in the Web of Science, Scopus, ACM, IEEE, and Science Direct databases from 2004 until 2019. The Kitchenham method applied for the systematic mapping allowed determining quantitative and qualitative results such as year of publication and documentary sources with the most significant number of papers. The main contribution of this research is the areas found of teachers' digital skills that are considered relevant in the Latin American context and its differences with other models. Finally, a discussion of the results and conclusions serves as a starting point for future research in other geographic areas and preliminary information to determine teachers' training needs to face the crisis. © 2021. All Rights Reserved.
ABSTRACT
The new reality imposed by COVID-19 has meant one of the greatest challenges that face-to-face university teaching has had to confront, as these higher education centres were suddenly forced to change from a face-to-face format to a virtual, contingent kind of teaching. More precisely, face-to-face communication at classrooms now must rely on synchronous videoconferences which have digitally "occupied" the space that was previously regulated in ordinary lessons. It all required using a wide range of technological applications, amongst which Google Meet stood out as one of the most popular. Based on this, our study set itself two objectives: (1) identifying the communication needs that university students have felt throughout this period of virtual teaching;and (2) verifying the extent to which Google Meet succeeded in meeting those needs. Seeking to accomplish the aforesaid goals, we involved 52 students from the Degree in Primary Education Teacher Training imparted at the University of Alicante. A mixed methodological approach was adopted, the software programs utilized for data processing purposes being SPSS v. 25 and AQUAD 7, which enabled us to carry out a descriptive study and a content analysis, respectively. In view of the results, and although the teaching staff have used a synchronous type of audiovisual communication suited to the demands of students, the degree of satisfaction amongst the latter is remarkably low. Something similar happens when it comes to Google Meet because, despite recognizing that it has positive aspects such as a certain degree of usefulness and enjoyment, they claim to have had serious difficulties in using it. Such findings lead us to conclude that a compelling need exists to fine tune the technological response that universities are giving before the situation caused by COVID-19.